TM4SF1 and central nervous system cancer: However, most studies indicated that the high expression of TM4SF1 is correlated with the T stage, TNM stage, and lymph node metastasis in various cancer types, including prostate (Allioli et al., 2011), ovarian (Gao et al., 2019), glioma (Wang et al., 2015), colorectal (Park et al., 2017), liver (Zhu et al., 2021), thyroid (Lee et al., 2019), lung (Ma et al., 2018), pancreatic (Cao et al., 2016), and breast cancers (Tu et al., 2012; Xing et al., 2017; Fan et al., 2019).