In an effort to identify the mechanisms through which COX-2 activity leads to CRC progression, we showed that its overexpression is enough to increase cancer cell aggressiveness (Stamatakis et al., 2015) through the regulation of the expression of genes we consider COX-2 activity effectors in the cancer cells (Hidalgo-Estévez et al., 2020). Here, PTGS2 is linked to cancer.