Ptgfr levels were lower, both in culture as in tumors, agreeing with the human tumor data (Hidalgo-Estévez et al., 2020) and the notion that, during cancer development and progression, the arachidonate/prostanoid pathway is tuned towards PGE2 production and detection, downregulating synthases and receptors of PGF2α and PGD2 (Cebola et al., 2015). This evidence concerns the gene PTGFR and neoplasm.