Among the upregulated genes were PTGES, DUSP10, PMEPA1, KLF4, TACSTD2, ZC3H12A, NFAT5, PTGFR, EGR1, TGFB1, INHBA, IL15RA, IL15, and NFKBIA. In this work, we overexpressed COX2 in the mouse colon cancer cell line CT26, to test if these genes were also upregulated. The gene discussed is EGR1; the disease is colonic neoplasm.