Among the upregulated genes were PTGES, DUSP10, PMEPA1, KLF4, TACSTD2, ZC3H12A, NFAT5, PTGFR, EGR1, TGFB1, INHBA, IL15RA, IL15, and NFKBIA. In this work, we overexpressed COX2 in the mouse colon cancer cell line CT26, to test if these genes were also upregulated. This evidence concerns the gene PMEPA1 and malignant colon neoplasm.