Moreover, when comparing data from our mouse model and from the TCGA colon cancer cohort analyzed using the UCSC Xena browser (https://xenabrowser.net/), the direction in the gene expression change, between normal tissue and tumor, was similar in both human and mouse for Ptgs2, Ptges, Dusp10, Klf4, Ptgfr, Egr1, Inhba1, Il15, and Nfkbia (not shown). This evidence concerns the gene KLF4 and malignant colon neoplasm.