Moreover, when comparing data from our mouse model and from the TCGA colon cancer cohort analyzed using the UCSC Xena browser (https://xenabrowser.net/), the direction in the gene expression change, between normal tissue and tumor, was similar in both human and mouse for Ptgs2, Ptges, Dusp10, Klf4, Ptgfr, Egr1, Inhba1, Il15, and Nfkbia (not shown). The gene discussed is PTGS2; the disease is neoplasm.