COX2 expression and activity has been has been long considered to play a very important role in colon tumorigenesis, cancer progression, and metastasis (Kawai et al., 2002; Cathcart et al., 2011), and its inhibition has been shown to have both great preventive and treatment value (Rothwell et al., 2011; Rothwell et al., 2021). This evidence concerns the gene PTGS2 and cancer.