CASP3 and breast cancer: In 2021, Jiang et al. reported that quercetin could increase the expression of GAS5, Bax, and caspase-3 and decrease the expressions of Notch1, Jagged1, Hes1, and Bcl-2 in MCF-7 cells, suggesting that quercetin can induce BC cell apoptosis by the GAS5/Notch1 signaling pathway (Jiang et al., 2021).