7β-(3-ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone, an ingredient isolated from Tussilago farfara L., was found to induce BC cell apoptosis by inhibiting JAK-STAT3 signaling and the expression of STAT3 target genes (Jang et al., 2019). The gene discussed is STAT3; the disease is breast cancer.