BAD and breast cancer: Pereyra-Vergara et al. (2020) reported that apoptosis induced by (−)-epicatechin in human BC cells was mediated by ROS to increase the proapoptotic proteins Bad and Bax. In 2020, Jia et al. (2020) proposed that formononetin could induce mitochondrial damage and decrease MMP in BC cells by inhibiting antioxidant enzyme activity and increasing ROS levels, ultimately activating caspase-3-mediated apoptosis.