According to another study by Yan et al., baicalein significantly reduced the expression of p-AKT, p-mTOR, NF-κB, and p-IκB in MCF-7 and MDA-MB-231 cells, demonstrating that baicalein can induce BC cell line apoptosis in animal models by inhibiting the PI3K/AKT signaling pathway (Yan et al., 2018). This evidence concerns the gene AKT1 and breast cancer.