In 2021, another report by Kim et al. (2021) indicated that silymarin induced BC cell apoptosis by regulating the MAPK signaling pathway, which increased the levels of Bax, cleaved PARP, cleaved caspase-9, and p-JNK and reduced the levels of Bcl-2, p-p38, and p-ERK. This evidence concerns the gene MAPK8 and breast cancer.