PARP1 and breast cancer: In 2013, Wang et al. (2013b) demonstrated that oridonin induced MDA-MB-231 BC cell apoptosis, which was associated with a reduction in the Bcl-2/Bax ratio, caspase-8, NF-κBp65, IKKα, IKKβ, and p-mTOR, and upregulated cleaved PARP, PPAR, and Fas expression levels.