Compared with the sham group, the protein expression of IGF1 in the I/R group was up-regulated, indicating that IGF1 was activated after cerebral ischemia; while the expression of IGF1 in SAC group decreased significantly when compared with I/R group, suggesting that SAC treatment may contribute to the recovery of cell function after stroke and the sensitivity of IGF1 decreased. Here, IGF1 is linked to brain ischemia.