In the pathological state of cerebral ischemia injury, VEGF and VEGFR2 are mainly overexpressed in endothelial cells, resulting in the destruction of tight junction, further leading to the destruction of BBB and vascular brain edema (Lafuente et al., 2006; Wang et al., 2019; Liu et al., 2020). This evidence concerns the gene KDR and brain ischemia.