HTT and Huntington disease: However, in the present study, we used a well-established HD striatal cell line that it has been extensively used to study the pathogenic mechanisms of mutant huntingtin, such as post-Golgi trafficking (Del Toro et al., 2006; Del Toro et al., 2009) or transcription factors (Xifró et al., 2011; Anglada-Huguet et al., 2012).