Reduced BDNF protein levels have been found in the striatum and cortex of multiple HD mouse models (Luthi-Carter, 2000; Zuccato et al., 2001; Gines et al., 2003b; Giralt et al., 2009) and diminished striatal BDNF levels have been associated with HD clinical motor disorders (Ferrer et al., 2000; Zuccato and Cattaneo, 2007). This evidence concerns the gene BDNF and Huntington disease.