An altered expression and activity of ERK1/2 and Akt have been found in multiple preclinical HD models and human tissue samples from people who died from HD, showing that it contributes to the development of the disease (Humbert et al., 2002; Colin et al., 2005; Apostol et al., 2006; Roze et al., 2008). The gene discussed is AKT1; the disease is Huntington disease.