In PD it has been described a downregulation of PAC1R in the caudate and putamen brain regions of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated macaque animals (Feher et al., 2018) and similar results have been obtained in motor cortex of amyotrophic lateral sclerosis (ALS) patients (Bonaventura et al., 2018). The gene discussed is ADCYAP1R1; the disease is amyotrophic lateral sclerosis.