Unexpectedly, no difference of cell growth inhibition was observed with either compounds to HCT116 cells regardless of MSI2 depletion, indicating that MSI2 was not required for the anti-cancer activities of either Ro 08-2750 or (-)gossypol in HCT116 cancer cells, although there are engagements between both compounds and MSI2 in vitro (Figures 3A,B). The gene discussed is MSI2; the disease is cancer.