MSI2 and amyotrophic lateral sclerosis: Notably, MSI2 depletion was significantly connected with neurological diseases, including amyotrophic lateral sclerosis, Huntington’s disease, Parkinson’s disease, and Prion’s disease, highlighting the critical role of MSI2 in the neuron system (Figure 1L), which is consistent to a previous study in that the pathological accumulation of MSI2 aggregates contributes to neurodegenerative proteinopathies (Montalbano et al., 2020).