MSI2 and colorectal cancer: The requirement of MSI2 for the survival of colorectal cancer HCT116 cells was also confirmed in xenograft assays, in that the MSI2 knockout tumors grew significantly slower than the WT ones, although the tumors initiated simultaneously (Figure 1F), and no obvious change of the body weight was observed in the WT and MSI2 knockout HCT116 xenograft mice (Figure 1F).