Different from HCT116 cells, the KEGG analysis in A549 cells revealed a close correlation between the MSI2 and immune response, in that the loss of MSI2 significantly regulated infection; TNFα, IL-17, and NF-κB signal pathways; complement and coagulation cascades; and genes related to rheumatoid arthritis, a chronic autoimmune disease (Figure 1L), rather than its known function in RNA processing. Here, NFKB1 is linked to rheumatoid arthritis.