It has been observed that Mycobacterium tuberculosis infection induces the expression of SOCS3 in phagocytes, which in turn stops STAT3 activation by inhibiting some of the STAT3-activating cytokine receptors (Rottenberg and Carow, 2014), as well as proliferation and survival of lung adenocarcinoma cells (Speth et al., 2019). Here, SOCS3 is linked to lung adenocarcinoma.