We observed that module-1 is statistically enriched by diverse biological processes and pathways, including cytokine-cytokine receptor interaction, T-cell activation, leukocyte activation, IL17, and TNF signaling pathways, Toll-like receptor signaling pathways, cellular responses to cytokine stimulus, rheumatoid arthritis, AGE-RAGE signaling pathways in diabetic complication and positive regulation of cytokine production. The gene discussed is TNF; the disease is rheumatoid arthritis.