P38 MAPK was found to promote the transdifferentiation of fibroblasts into myofibroblasts in Graves’ ophthalmopathy (Hou et al., 2021), H G et al. found that CuSO4 treatment may induce pulmonary fibrosis through the activation of EMT induced by P38 MAPKs pathways (Guo et al., 2021). Here, MAPK14 is linked to Graves ophthalmopathy.