MGLL and Alzheimer disease: Furthermore, Syal et al. reported that the activated aPKC-CBP pathway by metformin treatment could reverse impairment of neurogenesis and spatial memory in the 3xTg-AD mouse model by decreasing the expression of monoacylglycerol lipase (Mgll), a hydrolase-producing arachidonic acid (ARA) precursor pool, through degrading endocannabinoid 2-arachidonoyl glycerol (2-AG).