Metformin injection for 18 weeks attenuated the increase of phospho-tau phosphorylated at Ser396 and Thr231 in the hippocampus of obese, leptin-resistant mice with AD-associated brain changes through suppressing the activation of JNK instead of attenuating the decrease of PP2A (Li et al., 2012). This evidence concerns the gene MAPT and Alzheimer disease.