Also, oligomeric Aβ, which can bind both full-length TREM2 and sTREM2, induced shedding of sTREM2 for TREM2-overexpressing cells (Vilalta et al., 2021), suggesting that sTREM2 shedding may be induced prior to and during AD as a result of Aβ oligomerization. Here, TREM2 is linked to Alzheimer disease.