APOE and Alzheimer disease: Among, different vascular-associated genetic risk factors, those corresponding to ε4 allele of APOE (APOE ε4), phatidylinositol binding clathrin assembly protein (PICALM), clusterin (CLU) or sortilin related receptor-1 (SORL1) genes have been identified in AD (Sweeney et al., 2019).