CST3 and chronic kidney disease: Further study also gave 308 individuals aged 90 or older a PET scan and obtained the brain indices of Aβ deposition using a statistically defined region of interest (statROI), and found that PET statROI was not correlated with cystatin C and eGFR, indicating an independent association between cognition and chronic kidney disease (CKD), and the CKD-associated cognitive dysfunction largely reflects vascular rather than Aβ pathology (Lau et al., 2021).