GFAP and Alzheimer disease: In this study, we described a new mouse strain, created by crossing the 3xTg-AD model of AD (Oddo et al., 2003) with GFAP/EGFP mice (Nolte et al., 2001), in which we detected an intracellular expression of Aβ in pyramidal neurons in 3M animals which is earlier than in the original 3xTg-AD model.