LRP1 and Alzheimer disease: Qosa and Kaddoumi (2016) described the different clearance of Aβ in four mouse strains widely used for the development of AD mouse models. The authors observed a decreased expression of LRP1 protein, which is responsible for Aβ clearance in SJL/J mice compared to C57Bl/6, FVB/N, and BALB/c. They further reported that the brain degradation of Aβ decreases in BALB/c, FVB/N, and SJL/J mice after administration rifampicin, which is a commonly used antibiotic that has previously been found to increase Aβ clearance across the blood-brain barrier (Qosa et al., 2012).