MAPT and Alzheimer disease: The most frequently declared causes of AD comprise neurodegeneration driven by amyloid-β (Aβ) toxicity and tau pathology, synaptic dysfunction as well as the loss of synaptic density, glutamate excitotoxicity, and oxidative stress (Smith et al., 2000; Hardy and Selkoe, 2002; Ingelsson et al., 2004; Walton and Dodd, 2007; Kriska et al., 2021).