Antidepressant agomelatine, an agonist of MT1 and MT2 melatonin receptors and 5-hydroxytryptamine 2C receptor antagonist, is widely used for treating depression and insomnia in several neurogenerative diseases, including Parkinson’s disease (Green, 2011; Norman and Olver, 2019). The gene discussed is HTR2C; the disease is depressive symptom measurement.