Previous studies proved that the content of cerebral TGF-β1 was elevated in the AD mouse model (Das and Golde, 2006), and overexpressing TGF-β1 could aggravate Aβ deposition and AD-like vascular damage in mouse (Wyss-Coray et al., 1997; Ongali et al., 2010). The gene discussed is TGFB1; the disease is Alzheimer disease.