MAPT and Alzheimer disease: The main culprits in the pathogenesis of AD are Tau protein accumulation and β-amyloid (Aβ) aggregation, resulting in widespread atrophy of brain areas as well as degradation of the SCN (Huseby et al., 2019); PD involves a-synuclein aggregation and results in a more targeted degradation of dopaminergic (DA) neurons (Delenclos et al., 2019).