CTE is a distinctive tau protein-related neurodegenerative disease with unique characteristics including phosphorylated tau (p-TAU) accumulation in sulci and perivascular regions, microgliosis, and astrocytosis (DeKosky et al., 2013; Fesharaki-Zadeh, 2019; Smith et al., 2019). This evidence concerns the gene MAPT and neurodegenerative disease.