Moreover, MS induced the activation of PVN mast cells, which secreted numerous proinflammatory mediators that might involve in neighboring CRF neuronal activity, ultimately directly inducing visceral hypersensitivity in adulthood rats (Chen et al., 2021), implying central immuno-inflammatory process also taking part in the MS-induced visceral hypersensitivity. This evidence concerns the gene CRH and myeloid sarcoma.