IDH-wild-type diffuse astrocytic (NB: diffuse and astrocytic) tumors in adults, if microvascular proliferation or necrosis or telomerase reverse transcriptase (TERT) promoter mutation or epidermal growth factor receptor (EGFR) gene amplification or +7/-10 chromosome copy number changes are present, should be diagnosed as IDH-wild-type GBM. The gene discussed is EGFR; the disease is neuroblastoma.