EGFR and glioblastoma: In addition, it should be noted that IDH-wild-type diffuse astrocytic tumors in adults, if microvascular proliferation or necrosis or TERT promoter mutation or EGFR gene amplification or +7/−10 chromosome copy number changes are present, should be diagnosed as IDH-wild-type glioblastoma (Louis et al., 2017, 2021; Brat et al., 2018).