As CD8+PD-1+TCF1+ Texprog and CD8+PD-1+TCF1− Texterm were detected in HNSCC, we investigated their prognostic value in the Sun Yan-Sen University (SYSU) cohort with 102 patients (patient clinicopathological information is presented in Table S2), based on the density of these two subsets in the mIHC results. Here, TCF7 is linked to head and neck squamous cell carcinoma.