TCF7 and neoplasm: Tregs are increased within tumor sites of various tumor types in humans and mice, limiting the antitumor immune response.27 Tregs promote intratumoral T cell exhaustion by modulating the expression of several coinhibitors and the exhaustion-associated transcriptomic signature of CD8+ T cells.28 We, therefore, used flow cytometry to investigate the association between the percentages of Tregs and the ratios of TCF1+Texprog to TCF1−Texterm which represented the status of PD1+CD8+ Tex proportion.