Previous studies reported that high levels of tumor-infiltrating Foxp3+ Tregs were associated with better prognosis and locoregional control in HNSCC.35–37 However, Foxp3 is a crucial regulator of Tregs that is responsible for a substantial amount of their suppressive potential.38 This result indicates that the good prognosticator, Foxp3+ Tregs, might be accompanied by high levels of TCF1-Texterm. This evidence concerns the gene TCF7 and neoplasm.