It has been reported that tumor dLNs could act as key orchestrators of antitumor responses induced by ICB therapy and generate the TCF1+Texprog that seed the tumor.16 We also found that TCF1-Texterm expressed more GZMB and displayed a phenotype of greater polyfunctional TNFα+GZMB+IFNγ+ production, whereas TCF1+Texprog could produce more TNFα which plays an important role in T cell proliferation and survival.30,31. Here, GZMB is linked to neoplasm.