It has been well accepted that the tumor cells were always in hypoxia as a result of rapid proliferation.39,40 In hypoxic microenvironment, the accumulation of HIF1α can promote glycolysis of tumor cells and maintain the survival of tumor cells.41,42 Interestingly, the oxidative phosphorylation of mitochondria is not inhibited, but rather augmented in in some cancers.10 However, it remains ambiguous how the oxidative phosphorylation of tumor cells is enhanced. The gene discussed is HIF1A; the disease is neoplasm.