SENP1 and neoplasm: The signal pathways of HIF1α include PI3K-Akt-HIF1α pathway, SENP1-HIF1α pathway and MAPK-HIF1α pathway.7–9 Moreover, a number of studies demonstrated that oxidative phosphorylation was not damaged or even enhanced in some types of tumor cells, such as leukemias and endometrial carcinoma.10 Enhanced oxidative phosphorylation could further lead to hypoxia in tumor cells, but the mechanism for increased oxidative phosphorylation in tumor cells is still unclear.