Previous studies have demonstrated that tumor cells under survival pressure will undergo energy metabolism reprogramming and plays an important role in this process.31,32 In hypoxic microenvironment, accumulated HIF1α transcriptionally activates the expression of many genes which are involved in regulating the energy metabolism of tumor cells.33,34 However, the reprogramming of energy metabolism of tumor cells under hypoxia is an extremely complicated process. Here, HIF1A is linked to neoplasm.