CASP3 and neoplasm: It has been found that the increasing intracellular ROS and cleaved caspase-3 protein can promote pyroptosis of tumor cells by activated GSDME.46 Bo Zhou et al reported that mitochondrial membrane protein Tom20 could sense iron-activated ROS signaling and enhance pyroptosis in melanoma cells.47 In our study, we found that mitochondria-located circPUM1 was able to inhibit pyroptosis by modulating intracellular ATP level.