In this review, we will first give a brief overview of LRRK2 biology and its relevance in PD, followed by comparative discussion on currently available LRRK2-based mouse models, with a particular focus on LRRK2 knock-in (KI) mouse models, and several neuropathological and phenotypic aspects as they relate to PD, including striatal neurotransmission, locomotor function, mitochondrial dysfunction, autophagy-lysosomal pathway and synucleinopathies. Here, LRRK2 is linked to Parkinson disease.