Approximately 24% of LBs in idiopathic patients were LRRK2-positive, whereas in confirmed LRRK2-PD patients with G2019S mutation, the proportion of LRRK2-reactive LBs increased to 50% [173], implicating a pathogenic role of LRRK2 in synucleinopathies. Here, LRRK2 is linked to Parkinson disease.