Based on currently available LRRK2 KI mouse models, in the following sections we review several phenotypic aspects relevant to PD (Table 1), with a particular focus on models harbouring the most frequently occurring pathogenic variants G2019S and R1441C/G, on how they potentially mimic some of the early-stage pathogenic changes in PD. This evidence concerns the gene LRRK2 and Parkinson disease.