PGRMC1 and neoplasm: As compared with IR plus UTMD group, PGRMC1 overexpression markedly reversed UTMD-induced inhibition of autophagic flux and PGRMC1 expression, thereby abolishing the beneficial effect of UTMD on tumor size [(3.8 ± 1.1) mm2 vs. (8.0 ± 1.9) mm2, P < 0.05] or survival time [(67.2 ± 2.6) d vs. (40.0 ± 1.2) d, P = 0.0026] in glioblastoma-bearing mice, respectively (Fig. 9a–g).