TRERF1 and glioblastoma: As shown in Fig. 5a, b and Additional file 1: Fig. S2, UTMD induced an obvious increase in cell death and decrease in colony formation in IR-treated glioblastoma cells (P < 0.01); moreover, in the presence of 3-MA, BafA1 or RAPA, there was no significant effect on UTMD-induced cell death and inhibition of colony formation in IR-treated glioblastoma cells (P > 0.05).