Of note, the different myocardial uptake profiles in the two wild-type ATTR-CM patients enrolled may be a result of the different features of their disease as evidenced by their LVM values: 72 g for Patient A, and 298 g for Patient B. It is possible that Patient A was in earlier stages of cardiac amyloidosis, or that the CM may be (at least partially) attributed to other causes, such as pre-existing diabetes, whereas Patient B had more pronounced cardiac amyloid deposition. Here, TTR is linked to diabetes mellitus.