AKT1 and asthma: In addition, a study showed that luteolin regulated autophagy of allergic asthma by activating PI3K/AKT/mTOR (phosphatidylinositol 3-kinase/AKT Serine/Threonine Kinase 1/Mechanistic Target of Rapamycin Kinase) pathway and inhibiting beclin-1-phosphatidylinositol 3-kinase catalytic subunit type 3 complex, which suggested that leuteolin also participate in the development of asthma [15].