Furthermore, HSPB1, whose expression was inhibited in CAD tissue, was more closely related to immune response (‘T‐CELL RECEPTOR SIGNALLING PATHWAY’, ‘B‐CELL RECEPTOR SIGNALLING PATHWAY’ and ‘NATURAL KILLER CELL‐MEDIATED CYTOTOXICITY’), ‘REGULATION OF AUTOPHAGY’ and amino acid metabolism pathway. This evidence concerns the gene HSPB1 and coronary artery disorder.