Unreasonably, the high‐expression of HSPB1 activated the pathways such as ‘ARACHIDONIC ACID METABOLISM’, ‘STEROID HORMONE BIOSYNTHESIS’, ‘DILATED CARDIOMYOPATHY’, ‘VASCULAR SMOOTH MUSCLE CONTRACTION’, ‘TGF BETA SIGNALLING PATHWAY’, ‘HYPERTROPHIC CARDIOMYOPATHY HCM’ and ‘ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY ARVC’ that may induce CAD (Figure 5B). The gene discussed is HSPB1; the disease is coronary artery disorder.