This has been further demonstrated in studies in which resting serum acquired after long-term exercise programs or exercise-conditioned serum obtained after a single bout of exercise applied to cancer cell lines produces substantial suppression of growth [7–13], with evidence supporting the involvement of exercise-induced serological insulin-like growth factor-1 (IGF-1) axis alteration in prostate cancer cell growth suppression [7, 11–13]. The gene discussed is IGF1; the disease is Familial prostate cancer.