The neoexpression of globosides following TGF-β treatment is an interesting observation since Gb3 has been reported to be associated with tumor invasion and metastasis in many cancers, including lung cancer (89), colon cancer (90, 91), breast cancer (92), gastric adenocarcinoma (93), and pancreatic cancer (94). This evidence concerns the gene TGFB1 and familial pancreatic carcinoma.