In our study, the poor prognostic factors for OS in women with left-side IDC and HFrEF receiving TM were old age, CCI ≥ 1, advanced pT stages (pT2–4), advanced pN stages (pN1–3), hormone receptor negative status, and differentiation Grade II–III of (Table 2), which are consistent with factors in women with breast cancer without HFrEF reported in previous studies [48–52]. Here, NR4A1 is linked to breast cancer.