In addition, upregulation of UHMK1 to about doubled levels was found in 5-FU-resistant human colon cancer cells in HCT-116 background following increasing dosing of 5-FU for more than 6 months (GSE56322), suggesting the important roles of UHMK1 in the development of chemoresistance. This evidence concerns the gene UHMK1 and malignant colon neoplasm.