We portraited the properties of a candidate kinase to be: nuclear localization; known substrate of RNA binding or splicing regulator proteins [27]; reported or verified upregulation following drug treatments (especially 5-FU and analogs) [28]; relation to the protein secretion of cancer cells [29]; and/or association with multiple categories as indicated from GO enrichment in the DE analyses of the present study (Fig. 3c), particularly in those that also overlapped with the functional annotation of coilin or CBs. The gene discussed is COIL; the disease is cancer.