However, the results of a prospective multicentre European study released in 2020 identified a link between H. pylori seropositivity (51% of CRC cases), the vacA gene (36% of CRC cases), the Helicobacter cysteine rich protein (28% of CRC cases), and an elevated chance of acquiring CRC [76]. The gene discussed is SPARC; the disease is colorectal carcinoma.