KMT2A and acute myeloid leukemia: More recently, VNP20009 strain was shown to induce apoptosis in various leukaemia cell lines in vitro and in vivo. Significant inhibition in the proliferation of MLL-Af9-induced acute myeloid leukaemia (AML) cells (inhibition rate was 82.82%) and increased survival of AML mice was documented [160].