Kisspeptins are the endogenous cleavage products of the KiSS1 protein, they function as potent vasoconstrictors, and the response could comparable to angiotensin (Ang)-II in the coronary artery; In addition, Kisspeptins’ receptor, G protein-coupled receptor 54, is discretely located at atherosclerosis-prone vessels [45]. The gene discussed is KISS1R; the disease is atherosclerosis.