Consistent with intestine-specific KO mice exhibiting impaired dietary cholesterol uptake and decreased expression levels of Cd36 and Abca1 [17], HF/HCD-fed Atgl iTg mice had accelerated cholesterol uptake from the diet, as shown by decreased radioactivity in feces and elevated tracer concentrations in the circulation. The gene discussed is PNPLA2; the disease is hydrops fetalis.