In agreement with these results, metabolic characterization of WT and Atgl iTg mice with comparable body weight after 10 weeks of HF/HCD feeding (Fig. 6D) showed increased fatty acid utilization, calculated from VO2 and VCO2, by 11% and 6% during the day and night, respectively (Fig. 6E); glucose oxidation and food consumption remained unchanged (data not shown). This evidence concerns the gene PNPLA2 and hydrops fetalis.