Such combination of ACE2 and integrin-mediated virus spreading is likely one important mechanism to attribute to high contagiousness and high hospitalization/mortality rate of SARS-CoV-2 as summarized in the following disease progression: Initial ACE2 cell infection → cytokine release → integrin activation → non-ACE2 cell infection → more cytokine release → more integrin activation → more non-ACE2 cell infection → cytokine storm → severe symptoms/mortality. The gene discussed is ACE2; the disease is infection.