GH1 and Prader-Willi syndrome: A recent meta-analysis of GH treatment of adults with PWS, including 9 randomized controlled trials and 20 nonrandomized controlled trials, showed that body composition improved during 12 months of GH treatment with an increase in mean (95% CI) lean body mass of 1.95 kg (0.04-3.87 kg) and a reduction of mean (95% CI) fat mass of –2.23% (–4.10% to –0.36%) (33).