CASP1 and Alzheimer disease: Nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, functioning as the promoter of the innate immune system, is characterized by NLRP3/Caspase-1 activation, and its inhibition exerts neuroprotective effects in AD through restricting neuronal pyroptosis [9,10].