Further, we detected BACE1 expression in the hippocampus and found that compared with the sham group, BACE1 expression was markedly upregulated in the AD group; and compared with the AD + agomir NC group, BACE1 expression was markedly downregulated in the AD+miR-212-3p agomir (p < 0.05, Figure 5D). The gene discussed is BACE1; the disease is Alzheimer disease.