MicroRNAs (miRNAs), a class of short non-coding RNA normally with 22-23 nucleotides, are altered along with mitochondrial impairment, oxidative imbalance, tau phosphorylation, and neuron damage, and in turn, dysfunctional miRNAs continue to aggravate neuroinflammation and cognitive impairment [12-14]. Here, MAPT is linked to Cognitive impairment.