Among all AKI biomarkers, cell cycle arrest of urinary tissue inhibitor of metalloproteinase-2 (TIMP-2) and insulin-like growth factor-binding protein 7 (IGFBP7) is upregulated early after AKI onset and has been confirmed to be superior in the early detection of AKI [8]. The gene discussed is IGFBP7; the disease is acute kidney injury.