The predictive value of the [TIMP-2]*[IGFBP7] day 0 clinical risk prediction model was superior to that of the TIMP-2 day 0 and IGFBP7 day 0 clinical risk prediction models in predicting nonrecovery from AKI, which was supported by the DeLong test, IDI and NRI (Additional file 1: Table S1). This evidence concerns the gene IGFBP7 and acute kidney injury.