IL33 and pulmonary arterial hypertension: These alarmins include interleukin‐1β (IL‐1β), high‐mobility group box 1, S100A8/9 and interleukin‐33 (IL‐33) and, all are proposed to play a significant role in cellular mechanisms leading to PAH (Bauer et al., 2013; Humbert et al., 1995; Liu et al., 2018; Nakamura et al., 2018; Titone et al., 2014).