Tantalizingly, the preoperative administration of albumin to hypoalbuminemic patients decreased the incidence of AKI in off‐pump cardiac surgery patients but not on‐pump cardiac surgery patients, suggesting that cardiac injury or excess exogenous albumin may be necessary for the development of albumin‐mediated AKI in CRS‐1 (Lee et al., 2016). Here, ALB is linked to acute kidney injury.