For carbohydrates, Zhao et al. reported that APOE ε4 in mice impairs the insulin pathway by trapping the insulin receptors in endosomes [107], and hyperglycemia, in turn, facilitates the glycation of APOE and exacerbates AD pathogenesis [108], so that carbohydrate intake elevates AD risk synergistically with APOE ε4. Here, INSR is linked to Alzheimer disease.