The expression levels of ALPI, CNGB1, ELAVL3, GCGR, HS6ST3, and RORB in SGs-LC were significantly correlated with the survival rate of patients with LS and CA10, CLDN19, COL18A1, HTR4, SMKR1,TPH1, and NRAP with CRC. The gene discussed is SMKR1; the disease is laryngotracheoesophageal cleft.