Ultimately, 494 specific genes for LS and CRC (SGs-LC) were obtained, including PTCHD1, SYT4, and COPDA1, and 99 LS and endometrial-specific genes (SGs-LE) were obtained, including CDC20B, SLC10A4, and LY6K (Supplementary Table 1). Here, COPDA1 is linked to colorectal carcinoma.