TNNI3 and acute coronary syndrome: Given this theory and the data which suggested that patients with suspected acute coronary syndrome who had a detectable level of hs-cTnI ≥ 5 ng/L are at high risk of cardiac ischemic events (e.g. sevenfold greater risk of subsequent myocardial infarction in Bularga et al.’s study)12,13, a detectable level of hs-cTnI ≥ 5 ng/L could also be considered as a sign of the high risk of cardiac damage.