Analyzing the neighboring nodes and closely interacting proteins of CRTAM and SCGB3A1 (both, Tbio) in the STRING80 database, CRTAM and SCGB3A1 are directly/indirectly interacting with the well-established immune axises IL-1β/TNF〈 and TREM2-TYROBP, respectively, which are relevant to AD (Fig. 6c). This evidence concerns the gene SCGB3A1 and Alzheimer disease.