FZD5 and lung carcinoma: In lung cancer cells, Frizzled 1 can be inhibited by miR-135b, Frizzled 2 by miR-203, Frizzled 4 by miR-3127-5p and miR-204, Frizzled 5 by miR-29a, and Frizzled 7 by miR-27-3, generally leading to inhibition of oncogenic Wnt/β-catenin signaling18–23.