Further investigation of the immune suppressive signals in the TME revealed an overall higher expression of PD-L1 in the macrophage and antigen presenting cell subtypes as compared to stromal (Wilcoxon FDR corrected p < 2.2 × 10−16) and tumor cells (Wilcoxon FDR corrected p < 2.2 × 10−16) (Fig. S2t). Here, CD274 is linked to neoplasm.