Separately, tumor cells were clustered using k-means (k = 25, markers E-cadherin, Ki67, P21, PDL1, cCasp3, PSTAT1, and Vimentin) and annotated into seven metaclusters: epithelial cells, proliferating epithelial cells, epithelial-mesenchymal-transition (EMT) cells, proliferating EMT cells, mesenchymal cells, apoptotic cells, and functional epithelial cells. Here, MKI67 is linked to neoplasm.