Collectively, these findings suggest that in the BRCA1/2mut tumors, high Ki67 expression in proliferating epithelial cells results in improved immunosurveillance, with enhanced cell to cell interaction with CD4 + T-cells and CD8 + T-cells, whereas in the HRwt tumors the high-proliferative tumor cells are not spatially interacting with CD4 + or CD8 + T-cells. Here, BRCA1 is linked to neoplasm.