In hierarchical clustering of all cell-type proportions (Fig. 4a), the cell types clustered into two main groups, the first one characterized by tumor EMT and mesenchymal metaclusters, IBA1 + macrophages, and stromal metaclusters, and the second one characterized by other tumor metaclusters and immune cell subtypes, suggestive of a different patterns of immune activity in the tumor-rich and stromal-rich TMEs. Here, AIF1 is linked to neoplasm.