Interestingly, though the proportions of sGRP78+ cells coexpressing CD34, CD38, CD10 or CXCR4 were significantly higher in High-risk leukemia population, these samples showed the presence of a subgroup of double positive cells rather than a general increase of the positivity to the analyzed markers (Fig. 2C,D,F,G). This evidence concerns the gene CXCR4 and leukemia.