PSME3 and neurodegenerative disease: BX795 restored the expression of components of the proteasome complex and activators of the E2 and E3 ligase binding process (PSMA3, UCHL1, OTUB1, PSME3, CUL1, PSMD12, and UBA6), and VCP, an AAA ATPase that extracts ubiquitinated proteins from large protein complexes for degradation, previously shown to co-localize with protein aggregates in various neurodegenerative diseases (Fig. 5a).