,37 While the concept of combining PCT and CRP biomarkers has been demonstrated in three previous studies,38, 39, 40 one study was only able to show semi-quantitative detection by setting up positive/ negative cut-offs for PCT and CRP,39 and none was able to conduct clinical validation to prove the quantification accuracy of the relatively large dynamic range observed in sepsis patients: from 0·05 ng/mL to > 10 ng/mL for PCT, and from 1 mg/dL to > 25 mg/dL for CRP (which runs into the hook effect range). Here, CALCA is linked to Sepsis.