On the contrary, DSS administration alone failed to induce the formation of CRC lesions in both wt and Emilin-2−/− mice; however, the treatment was stopped at 12 weeks following the first DSS treatment, instead of the scheduled 16 weeks, due to severe suffering of the Emilin-2−/− mice. The gene discussed is EMILIN2; the disease is colorectal carcinoma.