Ruled out the possibility of a direct action of EMILIN-2 in CRC cell growth, based on the fact that the protocol to induce CRC carcinogenesis included the pro-inflammatory agent DSS, we next hypothesized that the increased tumor growth in Emilin-2−/− mice upon AOM/DSS treatment could depend on an altered inflammatory response. This evidence concerns the gene EMILIN2 and infectious otitis media.