BRAF and intestinal disorder: Furthermore, the MEXPRESS analyses indicated that a higher methylation of the EMILIN-2 gene was associated with higher rate of braf mutations (p = 0.040), higher number of colon polyps (p = 5.7e10− 6), increased lymphatic invasion (p = 0.040) as well as with the pathologic M status (p = 0.015) (Fig. S1).