In agreement with our hypothesis that the absence of EMILIN-2 may result in an increased activation of Wnt/β-catenin signaling pathway, one of the major drivers of CRC growth [29], Emilin-2−/− mice developed a significant higher number of tumors compared with the wt littermates (Fig. 2D,F). This evidence concerns the gene EMILIN2 and colorectal carcinoma.