Thus, based on the finding that epigenetic modifications of EMILIN-2 gene occur in a number of solid tumors [36], we first evaluated the levels of methylation of the EMILIN-2 gene in the TCGA COAD cohort of 477 CRC patients and found that the EMILIN-2 gene carries many methylation sites (Fig. S1). Here, EMILIN2 is linked to colorectal carcinoma.