The massive presence of macrophages was observed in the AOM/DSS (colitis-associated CRC) model, as well as in the AOM-induced (sporadic) model (Fig. S8B), suggesting that EMILIN-2 affects not only the immunosurveillance in the early phases of CRC development, but also the immune environment in established tumors (Fig. 5C and Fig. S8B). The gene discussed is EMILIN2; the disease is infectious otitis media.