The down-regulation of EMILIN-2 expression in CRC patients was also confirmed at the mRNA level, as assessed in a cohort of 121 patients (GEO ID: GSE3629 [44]), as well as at the protein level in a cohort of 110 patients available at the cBioportal public dataset [50] (Fig. 1 A,B, respectively). This evidence concerns the gene EMILIN2 and colorectal carcinoma.