To investigate if the long-term allergic conditions could trigger autoimmunity leading to the production of autoantibodies, we characterized the profile of autoantibodies (IgG) (nRNP, Sm, SS-A, Ro-52, SS-B, Scl-70, PM-Scl, Jo-1, CENP B, PCNA, dsDNA, NUCL, Histones, rib-P, AMA-M2) in the serum of patients. The gene discussed is CENPB; the disease is Autoimmunity.