A 60-year-old woman with prior intravenous drug use, HIV (CD4 600 cells/mm3, undetectable HIV VL, on Abacavir/Lamivudine + Raltegravir), recently cured hepatitis C virus, cirrhosis, and Stage 1 CKD presented to the ED with cough, headache, dyspnea, fevers, sore throat, myalgias, and fatigue. This evidence concerns the gene CD4 and chronic kidney disease.