A 39-year-old man with HIV (CD4 354 cells/mm3, HIV VL undetectable, on Elvitegravir/Cobicistat/Emtricitabine/Tenofovir-alafenamide plus Darunavir 800 mg daily) and HTN presented with cough, dyspnea, fevers, sore throat, myalgias, and fatigue. This evidence concerns the gene CD4 and hypertensive disorder.